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KMID : 0613820170270060680
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Journal of Life Science
2017 Volume.27 No. 6 p.680 ~ p.687
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Lactobacillus plantarum-fermented Opuntia humifusa Extracts (fOH) Increases the Anti-obesity Activity in Mice Fed a 45% Kcal High Fat Diet
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Jung Young-Mi
Ku Sae-Kwang
Lee Dong-Sub
Kwon Ki-Sang
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Abstract
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Recently, there has been a marked increase in the use of bioactive products resulting from the fermentation of natural substances by microorganisms. In this study, Opuntia humifusa (OH) was fermented using Lactobacillus plantarum (fermented Opuntia humifusa; fOH). We then examined the anti-obesity effect of fOH in mice fed a 45% Kcal high fat diet (HFD). In this study, mice were treated with fOH concentrations of 100, 200, and 400 mg/kg. The mice in the control group were treated with OH at a concentration of 400 mg/kg based on previous animal experiments. All of the mice given a continuous HFD showed an increase in their weight, the density of abdominal fat, and the accumulated periovaric and abdominal fat. All of these obesity-linked factors, however, were significantly decreased in the groups treated with fOH at concentrations of 200 and 400 mg/kg. Mice treated with fOH at 100 mg/kg did not show a significant decrease in these obesity-linked factors compared to the control group. It appears that fOH fermented by L. plantarum has a greater anti-obesity effect in HFD-supplied mice compared to unfermented OH. While further studies of fOH are needed to examine its effect on obesity, hyperlipidemia, hepatic steatosis, renal function, and type II diabetes with its relevant complications, fOH may have significant therapeutic potential in the treatment of metabolic syndrome.
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KEYWORD
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Anti-obesity, HFD mice, Lactobacillus plantarum-fermented Opuntia humifusa fruit extracts (fOH)
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